Detalhe da pesquisa
1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34822784
2.
Enantioselective total synthesis of (-)-minovincine in nine chemical steps: an approach to ketone activation in cascade catalysis.
Angew Chem Int Ed Engl
; 52(43): 11269-72, 2013 Oct 18.
Artigo
Inglês
| MEDLINE | ID: mdl-24000234
3.
Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.
J Med Chem
; 63(14): 7906-7920, 2020 07 23.
Artigo
Inglês
| MEDLINE | ID: mdl-32558564
4.
Relaying stereochemistry through aromatic ureas: 1,9 and 1,15 remote stereocontrol.
Chem Commun (Camb)
; (5): 547-9, 2009 Feb 07.
Artigo
Inglês
| MEDLINE | ID: mdl-19283286
5.
Helix persistence and breakdown in oligoureas of metaphenylenediamine: apparent diastereotopicity as a spectroscopic marker of helix length in solution.
J Am Chem Soc
; 130(45): 15193-202, 2008 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-18844355
6.
Conformation and stereodynamics of 2,2'-disubstituted N,N'-diaryl ureas.
Org Biomol Chem
; 6(16): 2908-13, 2008 Aug 21.
Artigo
Inglês
| MEDLINE | ID: mdl-18688483
7.
Achieving conformational control over C-C, C-N and C-O bonds in biaryls, N,N'-diarylureas and diaryl ethers: advantages of a relay axis.
Chem Commun (Camb)
; (7): 754-6, 2007 Feb 21.
Artigo
Inglês
| MEDLINE | ID: mdl-17392973
8.
Ring-selective functionalization of N,N'-diarylureas by regioselective N-alkylation and directed ortho metalation.
Org Lett
; 7(15): 3147-50, 2005 Jul 21.
Artigo
Inglês
| MEDLINE | ID: mdl-16018607
9.
Asymmetric decarboxylative allylation of oxindoles.
Org Lett
; 13(16): 4264-7, 2011 Aug 19.
Artigo
Inglês
| MEDLINE | ID: mdl-21776973
10.
Slow interconversion of enantiomeric conformers or atropisomers of anilide and urea derivatives of 2-substituted anilines.
Org Biomol Chem
; 3(17): 3173-83, 2005 Sep 07.
Artigo
Inglês
| MEDLINE | ID: mdl-16106298
11.
A practical flow reactor for continuous organic photochemistry.
J Org Chem
; 70(19): 7558-64, 2005 Sep 16.
Artigo
Inglês
| MEDLINE | ID: mdl-16149784